【结 构 式】 |
【分子编号】43552 【品名】(3,3-diphenylpropoxy)(methyl)dimethylene-lambda(6)-sulfane 【CA登记号】 |
【 分 子 式 】C18H22OS 【 分 子 量 】286.43808 【元素组成】C 75.48% H 7.74% O 5.59% S 11.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III), which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.
【1】 Shiota, T.; et al.; Chemokine receptor antagonistic activities and structure-activity relationship of novel homopiperazine derivatives. 19th Symp Med Chem and 8th Annu Meet Div Med Chem Jpn (Nov 17-19, Tokyo) 1999, Abst 1P-10. |
【2】 Shiota, T.; Yamagami, S.; Kataoka, K.; Endo, N.; Tanaka, H.; Barnum, D.; Greene, J.; Moree, W.; Ramirez-Weinhouse, M.; Tarby, C. (Teijin Ltd.); Diarylalkyl cyclic diamine derivs. as chemokine receptor antagonists. EP 0914319; JP 1997309877; WO 9744329 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 43552 | (3,3-diphenylpropoxy)(methyl)dimethylene-lambda(6)-sulfane | C18H22OS | 详情 | 详情 | |
(II) | 25030 | 1,4-diazepane | 505-66-8 | C5H12N2 | 详情 | 详情 |
(III) | 43553 | 1-(3,3-diphenylpropyl)-1,4-diazepane | C20H26N2 | 详情 | 详情 | |
(IV) | 43554 | 4-(bromomethyl)phenyl methyl sulfone; [4-(bromomethyl)phenyl](methyl)dioxo-lambda(6)-sulfane | 53606-06-7 | C8H9BrO2S | 详情 | 详情 |
Extended Information