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【结 构 式】 
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【分子编号】43338 【品名】1,3-benzodioxol-5-ylmethyl isothiocyanate; 5-(isothiocyanatomethyl)-1,3-benzodioxole 【CA登记号】4430-47-1 |
【 分 子 式 】C9H7NO2S 【 分 子 量 】193.22612 【元素组成】C 55.94% H 3.65% N 7.25% O 16.56% S 16.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.
| 【1】 Matsuno, K.; et al.; Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline deri. J Med Chem 2002, 45, 20, 4513. |
| 【2】 Matsuno, K.; Ichimura, M.; Nomoto, Y.; Fujiwara, S.; Ide, S.; Tsukuda, E.; Irie, J.; Oda, S. (Kyowa Hakko Kogyo Co., Ltd.); Nitrogenous heterocyclic cpds. EP 0882717; WO 9814431 . |
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