CT-052923, -Drug Synthesis Database

【结构式】

【药物名称】CT-052923

【化学名称】N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin- 4-yl)piperazine-1-carbothioamide

【CA登记号】

【分子式】C₂₃H₂₅N₅O₄S

【分子量】467.5508

【开发单位】COR Therapeutics; Kyowa Hakko

【药理作用】ONCOLYTIC DRUGS, INHIBITORS OF SIGNAL TRANSDUCTION PATHWAYS

合成路线1

The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.

参考文献中间体

【1】 Matsuno, K.; et al.; Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline deri. J Med Chem 2002, 45, 20, 4513.
【2】 Matsuno, K.; Ichimura, M.; Nomoto, Y.; Fujiwara, S.; Ide, S.; Tsukuda, E.; Irie, J.; Oda, S. (Kyowa Hakko Kogyo Co., Ltd.); Nitrogenous heterocyclic cpds. EP 0882717; WO 9814431 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	41610	6,7-dimethoxy-4-(1-piperazinyl)quinazoline; 6-methoxy-4-(1-piperazinyl)-7-quinazolinyl methyl ether		C₁₄H₁₈N₄O₂	详情	详情
(II)	43338	1,3-benzodioxol-5-ylmethyl isothiocyanate; 5-(isothiocyanatomethyl)-1,3-benzodioxole	4430-47-1	C₉H₇NO₂S	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(2)