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【结 构 式】

【分子编号】43196

【品名】(3S)-N-(3-benzoylphenyl)-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide

【CA登记号】

【 分 子 式 】C25H19N3O2S

【 分 子 量 】425.51088

【元素组成】C 70.57% H 4.5% N 9.88% O 7.52% S 7.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

This compound has been obtained by two similar ways: 1. By condensation of the benzophenone derivative (I) with O-(1-methylpiperidin-4-yl)hydroxylamine by means of K2CO3 in propanol. 2. The reaction of benzophenone derivative (I) with hydroxylamine by means of K2CO3 in propanol gives the corresponding oxime (III), which is finally alkylated with 4-chloro-1-methylpiperidine (IV) by means of NaH in DMF.

1 Floch, A.; Soler, F.; Cavero, I.; Lavé, D.; Robaut, C.; RP 66681B, a water-soluble pyrrolothiazole derivative with potent and selective PAF receptor antagonist properties. Drugs Fut 1992, 17, 3, 207.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 43196 (3S)-N-(3-benzoylphenyl)-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide C25H19N3O2S 详情 详情
(II) 43197 O-(1-methyl-4-piperidinyl)hydroxylamine; 4-(aminooxy)-1-methylpiperidine C6H14N2O 详情 详情
(III) 43198 (3S)-N-[3-[(hydroxyimino)(phenyl)methyl]phenyl]-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide C25H20N4O2S 详情 详情
(IV) 20949 4-Chloro-1-methylpiperidine; 4-Chloro-N-methylpiperidine; N-methyl-4-chloropiperidine 55770-77-4 C6H12ClN 详情 详情
Extended Information