(3S)-N-[3-[(hydroxyimino)(phenyl)methyl]phenyl]-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】43198

【品名】(3S)-N-[3-[(hydroxyimino)(phenyl)methyl]phenyl]-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide

【CA登记号】

【分子式】C₂₅H₂₀N₄O₂S

【分子量】440.52556

【元素组成】C 68.16% H 4.58% N 12.72% O 7.26% S 7.28%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

This compound has been obtained by two similar ways: 1. By condensation of the benzophenone derivative (I) with O-(1-methylpiperidin-4-yl)hydroxylamine by means of K2CO3 in propanol. 2. The reaction of benzophenone derivative (I) with hydroxylamine by means of K2CO3 in propanol gives the corresponding oxime (III), which is finally alkylated with 4-chloro-1-methylpiperidine (IV) by means of NaH in DMF.

参考文献中间体

合成目标

【1】 Floch, A.; Soler, F.; Cavero, I.; Lavé, D.; Robaut, C.; RP 66681B, a water-soluble pyrrolothiazole derivative with potent and selective PAF receptor antagonist properties. Drugs Fut 1992, 17, 3, 207.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43196	(3S)-N-(3-benzoylphenyl)-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide		C₂₅H₁₉N₃O₂S	详情	详情
(II)	43197	O-(1-methyl-4-piperidinyl)hydroxylamine; 4-(aminooxy)-1-methylpiperidine		C₆H₁₄N₂O	详情	详情
(III)	43198	(3S)-N-[3-[(hydroxyimino)(phenyl)methyl]phenyl]-3-(3-pyridinyl)-1H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide		C₂₅H₂₀N₄O₂S	详情	详情
(IV)	20949	4-Chloro-1-methylpiperidine; 4-Chloro-N-methylpiperidine; N-methyl-4-chloropiperidine	55770-77-4	C₆H₁₂ClN	详情	详情

Extended Information