4-(4-methoxyphenyl)-1-(4-phenylbutyl)piperidine; methyl 4-[1-(4-phenylbutyl)-4-piperidinyl]phenyl ether -Drug Synthesis Database

【结构式】

【分子编号】43155

【品名】4-(4-methoxyphenyl)-1-(4-phenylbutyl)piperidine; methyl 4-[1-(4-phenylbutyl)-4-piperidinyl]phenyl ether

【CA登记号】

【分子式】C₂₂H₂₉NO

【分子量】323.4784

【元素组成】C 81.69% H 9.04% N 4.33% O 4.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The alkylation of 4-(4-methoxyphenyl)piperidine (I) with 4-phenylbutyl tosylate (II) provided the tertiary amine (III). The methyl ether group of (III) was then cleaved using BBr3 to furnish the title phenol.

参考文献中间体

合成目标

【1】 Bigge, C.F.; Cai, S.X.; Weber, E.; Woodward, R.; Keana, J.F.W.; Lan, N.C.; Guzikowski, A.P.; Zhou, Z.-L.; Yeun, P.-W. (CoCensys, Inc.; Pfizer Inc.); 4-Substd. piperidine analogs and their use as subtype selective NMDA receptor antagonists. EP 0869792; JP 2000500773; WO 9723216 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43153	4-(4-methoxyphenyl)piperidine; methyl 4-(4-piperidinyl)phenyl ether	67259-62-5	C₁₂H₁₇NO	详情	详情
(II)	43154	4-phenylbutyl 4-methylbenzenesulfonate		C₁₇H₂₀O₃S	详情	详情
(III)	43155	4-(4-methoxyphenyl)-1-(4-phenylbutyl)piperidine; methyl 4-[1-(4-phenylbutyl)-4-piperidinyl]phenyl ether		C₂₂H₂₉NO	详情	详情

Extended Information