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【结 构 式】 
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【分子编号】43153 【品名】4-(4-methoxyphenyl)piperidine; methyl 4-(4-piperidinyl)phenyl ether 【CA登记号】67259-62-5 |
【 分 子 式 】C12H17NO 【 分 子 量 】191.27312 【元素组成】C 75.35% H 8.96% N 7.32% O 8.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The alkylation of 4-(4-methoxyphenyl)piperidine (I) with 4-phenylbutyl tosylate (II) provided the tertiary amine (III). The methyl ether group of (III) was then cleaved using BBr3 to furnish the title phenol.
| 【1】 Bigge, C.F.; Cai, S.X.; Weber, E.; Woodward, R.; Keana, J.F.W.; Lan, N.C.; Guzikowski, A.P.; Zhou, Z.-L.; Yeun, P.-W. (CoCensys, Inc.; Pfizer Inc.); 4-Substd. piperidine analogs and their use as subtype selective NMDA receptor antagonists. EP 0869792; JP 2000500773; WO 9723216 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43153 | 4-(4-methoxyphenyl)piperidine; methyl 4-(4-piperidinyl)phenyl ether | 67259-62-5 | C12H17NO | 详情 | 详情 |
| (II) | 43154 | 4-phenylbutyl 4-methylbenzenesulfonate | C17H20O3S | 详情 | 详情 | |
| (III) | 43155 | 4-(4-methoxyphenyl)-1-(4-phenylbutyl)piperidine; methyl 4-[1-(4-phenylbutyl)-4-piperidinyl]phenyl ether | C22H29NO | 详情 | 详情 |
Extended Information