N-[[(2S)-1-ethylpyrrolidinyl]methyl]-6-hydroxy-2,3-dimethoxybenzamide -Drug Synthesis Database

【结构式】

【分子编号】42908

【品名】N-[[(2S)-1-ethylpyrrolidinyl]methyl]-6-hydroxy-2,3-dimethoxybenzamide

【CA登记号】

【分子式】C₁₆H₂₄N₂O₄

【分子量】308.37764

【元素组成】C 62.32% H 7.84% N 9.08% O 20.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The lithiation of N-(1-ethylpyrroidin-2(S)-ylmethyl)-2,3-dimethoxybenzamide (I) with n-BuLi gives the dilithium salt (II), which by treatment with butyl borate, H2O2 and ammonium chloride yields N-(1-ethylpyrrolidin-2(S)-ylmethyl)-6-hydroxy-2,3-dimethoxybenzamide (III). Finally, this compound is iodinated with 123INa and chloramine T.

参考文献中间体

合成目标

【1】 Hogberg, M.; Novel substituted salicylamides and benzamides as selective dopamine D2-receptor antagonists. Drugs Fut 1991, 16, 4, 333.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	42899	N-[[(2S)-1-ethylpyrrolidinyl]methyl]-2,3-dimethoxybenzamide	C₁₆H₂₄N₂O₃	详情	详情
(II)	42900	lithium [2-[([[(2S)-1-ethylpyrrolidinyl]methyl]imino)(oxido)methyl]-3,4-dimethoxyphenyl]lithium	C₁₆H₂₂Li₂N₂O₃	详情	详情
(III)	42908	N-[[(2S)-1-ethylpyrrolidinyl]methyl]-6-hydroxy-2,3-dimethoxybenzamide	C₁₆H₂₄N₂O₄	详情	详情

Extended Information