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【结 构 式】 
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【分子编号】42818 【品名】 【CA登记号】 |
【 分 子 式 】C9H12Cl2N3O5PS 【 分 子 量 】376.156662 【元素组成】C 28.74% H 3.22% Cl 18.85% N 11.17% O 21.27% P 8.23% S 8.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (I) with phosphoryl chloride gave intermediate (II). Acid chloride (II) was then condensed with myristyl alcohol (III) to furnish the desired phosphate ester, which was finally converted to the title sodium salt by treatment with aqueous NaOH.
| 【1】 Kawaguchi, T.; et al.; Enzymatic reactivity and anti-tumor activity of 1-(beta-D-arabinofuranosyl)-2-thiocytosine derivatives. Chem Pharm Bull 2000, 48, 4, 454. |
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