|
【结 构 式】 
|
【药物名称】 【化学名称】1-[5'-O-[Hydroxy(tetradecyloxy)phosphoryl]-beta-D-arabinofuranosyl]-2-thiocytosine sodium salt 【CA登记号】205826-63-7 (free acid), 205826-62-6 (Li salt) 【 分 子 式 】C23H41N3NaO7PS 【 分 子 量 】557.62672 |
【开发单位】Toagosei (Originator) 【药理作用】Oncolytic Drugs, Antimetabolites |
合成路线1
The condensation of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (I) with phosphoryl chloride gave intermediate (II). Acid chloride (II) was then condensed with myristyl alcohol (III) to furnish the desired phosphate ester, which was finally converted to the title sodium salt by treatment with aqueous NaOH.
| 【1】 Kawaguchi, T.; et al.; Enzymatic reactivity and anti-tumor activity of 1-(beta-D-arabinofuranosyl)-2-thiocytosine derivatives. Chem Pharm Bull 2000, 48, 4, 454. |
Extended Information