(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】42597

【品名】(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid

【CA登记号】

【分子式】C₂₀H₂₄N₂O₃

【分子量】340.42224

【元素组成】C 70.57% H 7.11% N 8.23% O 14.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title yohimbine dimer was prepared by coupling yohimbinic acid (I) with 1,6-hexanediamine (II) in the presence of dicyclohexylcarbodiimide and hydroxybenzotriazole, followed by conversion to the dihydrochloride salt.

参考文献中间体

合成目标

【1】 Miller, D.D.; Lalchandani, S.; Feller, D.R.; Sun, G.; Lei, L.; Zheng, W.; Yohimbine dimers exhibiting binding selectivities for human alpha2a - versus alpha2b adrenergic receptors. Bioorg Med Chem Lett 2000, 10, 7, 627.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42597	(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid		C₂₀H₂₄N₂O₃	详情	详情
(II)	22344	1,6-hexanediamine; 6-aminohexylamine	124-09-4	C₆H₁₆N₂	详情	详情

Extended Information