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【结 构 式】 
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【药物名称】 【化学名称】N,N'-Bis[(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13b,14,14a-dodecahydrobenz[g]indolo[2,3-a]quinolizin-1-ylcarbonyl]hexane-1,6-diamine dihydrochloride 【CA登记号】 【 分 子 式 】C46H62Cl2N6O4 【 分 子 量 】833.95084 |
【开发单位】University of Mississippi (Originator), University of Tennessee, Memphis (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, alpha2A(2D)-Adrenoceptor Antagonists |
合成路线1
The title yohimbine dimer was prepared by coupling yohimbinic acid (I) with 1,6-hexanediamine (II) in the presence of dicyclohexylcarbodiimide and hydroxybenzotriazole, followed by conversion to the dihydrochloride salt.
| 【1】 Miller, D.D.; Lalchandani, S.; Feller, D.R.; Sun, G.; Lei, L.; Zheng, W.; Yohimbine dimers exhibiting binding selectivities for human alpha2a - versus alpha2b adrenergic receptors. Bioorg Med Chem Lett 2000, 10, 7, 627. |
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