2-butyn-1-ol -Drug Synthesis Database

【结构式】

【分子编号】42514

【品名】2-butyn-1-ol

【CA登记号】764-01-2

【分子式】C₄H₆O

【分子量】70.09104

【元素组成】C 68.55% H 8.63% O 22.83%

与该中间体有关的原料药合成路线共 3 条

合成路线1 合成路线2 合成路线3

合成路线1

该中间体在本合成路线中的序号：(IX)

Drospirenone can been obtained by different ways: 1) Fermentation of 3beta-hydroxy-15beta,16beta-methylene-5-androsten-17-one (I) with Botryodiplodia malorum gives the corresponding 7beta-hydroxy derivative (II), which is regioselectively acylated with pivaloyl anhydride and DMAP in pyridine to yield the 3beta-pivaloyloxy steroid (III). The epoxidation of (III) with tert-butylhydroperoxide catalyzed by VO(acetonylacetonate)2 complex affords the corresponding epoxide (IV), which is treated with PPh3 and CCl4 in dichloromethane to provide the 7alpha-chloro derivative (V). Reaction of (V) with Zn in AcOH/THF gives 5beta-hydroxy-3beta-(pivaloyloxy)-15beta,16beta-methylene-6-androsten-17-one (VI), which is hydrolyzed with KOH and NaClO4 in methanol/THF to provide 3beta,5beta-dihydroxy-15beta,16beta-methylene-6-androsten-17-one (VII). The cyclopropanation of (VII) with diiodomethane and Zn in hot ethylene glycol dimethylether gives 3beta,5beta-dihydroxy-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-one (VIII), which is condensed with propargyl alcohol (IX) by means of EtOK in THF, yielding 17alpha-(3-hydroxy-1-propynyl)-6beta,7beta:15beta,16beta-dimethyleneandrostan-3beta,5beta,17beta-triol (X). The hydrogenation of (X) with H2 over either Pd/C in THF/methanol/pyridine (1) or Pd/CaCO3 in THF/2-propanol affords the corresponding 17alpha-(3-hydroxypropyl) derivative (XI), which is finally oxidized, lactonized and dehydrated by means of CrO3 in hot pyridine/water. Similar synthetic pathways have been described replacing the pivaloyl-protecting group with either tert-butyldimethylsilyl (TBDMS), dimethyl(3-methylbutyl)silyl or tribenzylsilyl groups: 2) Alternatively, the 17alpha-(3-hydroxypropyl) derivative (XI) can be oxidized with RuCl3 and NaBrO3 in hot acetonitrile/water to give the 3-hydroxyspirolactone (XII), which is finally dehydrated by means of TsOH in THF.

参考文献中间体

合成目标

【1】 Angew Chem 1982, 94, 718-719.
【2】 Norman, P.; Castaner, R.M.; Castaner, J.; Drospirenone. Drugs Fut 2000, 25, 12, 1247.
【3】 Nickisch, K.; Wiechert, R.; Laurent, H.; Petzoldt, K.; Bittler, D. (Schering AG); Process for preparing 3beta,7beta-dihydroxy-DELTA5-steroids. DE 3042136; EP 0051143; JP 1982122798; US 4416985; US 4614616 .
【4】 Mohr, J.-T.; Nickisch, K. (Schering AG); Process for producing drospirenone (6beta,7beta;15beta,16beta-dimethylene-3-oxo-17alpha-preg-4-en-21,17-carbolactone, DRSP), as well as 7alpha-(3-hydroxy-1-propyl)-6beta,7beta;15beta,16beta-dimethylene-5beta-androstane-3beta,5,17beta-triol (ZK 92836) and . DE 19633685; US 6121465; WO 9806738 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42507	(2S,4aR,4bS,6aS,7aS,8aS,8bR,8cR)-2-hydroxy-4a,6a-dimethyl-2,3,4,4a,4b,5,6,6a,7a,8,8a,8b,8c,9-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(1H)-one		C₂₀H₂₈O₂	详情	详情
(II)	42508	(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,9R)-2,9-dihydroxy-4a,6a-dimethyl-2,3,4,4a,4b,5,6,6a,7a,8,8a,8b,8c,9-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(1H)-one		C₂₀H₂₈O₃	详情	详情
(III)	42509	(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,9R)-9-hydroxy-4a,6a-dimethyl-7-oxo-1,2,3,4,4a,4b,5,6,6a,7,7a,8,8a,8b,8c,9-hexadecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-2-yl pivalate		C₂₅H₃₆O₄	详情	详情
(IV)	42518	(1aS,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,10R,10aR)-10-hydroxy-5a,7a-dimethyl-8-oxohexadecahydro-2H-cyclopropa[4',5']cyclopenta[1',2':1,2]phenanthro[8a,9-b]oxiren-3-yl pivalate		C₂₅H₃₆O₅	详情	详情
(V)	42510	(1aS,3S,5aR,5bS,7aS,8aS,9aS,9bS,9cR,10S,10aS)-10-chloro-5a,7a-dimethyl-8-oxohexadecahydro-2H-cyclopropa[4',5']cyclopenta[1',2':1,2]phenanthro[8a,9-b]oxiren-3-yl pivalate		C₂₅H₃₅ClO₄	详情	详情
(VI)	42511	(2S,4aR,4bS,6aS,7aS,8aS,8bR,8cR,10aR)-10a-hydroxy-4a,6a-dimethyl-7-oxo-1,2,3,4,4a,4b,5,6,6a,7,7a,8,8a,8b,8c,10a-hexadecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-2-yl pivalate		C₂₅H₃₆O₄	详情	详情
(VII)	42512	(2S,4aR,4bS,6aS,7aS,8aS,8bR,8cR,10aR)-2,10a-dihydroxy-4a,6a-dimethyl-2,3,4,4a,4b,5,6,6a,7a,8,8a,8b,8c,10a-tetradecahydrocyclopropa[4,5]cyclopenta[1,2-a]phenanthren-7(1H)-one		C₂₀H₂₈O₃	详情	详情
(VIII)	42513	(1aR,1bR,3S,5aR,5bS,7aS,8aS,9aS,9bR,9cR,9dR)-1b,3-dihydroxy-5a,7a-dimethyloctadecahydro-8H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one		C₂₁H₃₀O₃	详情	详情
(IX)	42514	2-butyn-1-ol	764-01-2	C₄H₆O	详情	详情
(X)	42515	(1aR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bR,9cR,9dR)-8-(3-hydroxy-1-propynyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol		C₂₄H₃₄O₄	详情	详情
(XI)	42516	(1aR,3S,5aR,5bS,7aS,8S,8aS,9aS,9bR,9cS,9dR)-8-(3-hydroxypropyl)-5a,7a-dimethyloctadecahydro-1bH-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-1b,3,8-triol		C₂₄H₃₈O₄	详情	详情
(XII)	42517			C₂₄H₃₂O₄	详情	详情

合成路线2

该中间体在本合成路线中的序号：(II)

N-(2-Butynyloxy)phthalimide (III) was obtained by the Mitsunobu coupling between 2-butyn-1-ol (II) and N-hydroxyphthalimide (I). Subsequent hydrazinolysis of (III) gave the O-alkynyl hydroxylamine (IV). This was finally condensed with quinuclidin-3-one (V) in methanol to furnish the corresponding oxime.

参考文献中间体

合成目标

【1】 Go, M.-L.; Loke, W.-K.; Sim, M.-K.; Somanadhan, B.; Quinuclidinone O-alkynyloximes with muscarinic agonist activity. Bioorg Med Chem 2002, 10, 1, 207.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13505	N-Hydroxyphthalimide; 2-Hydroxy-1H-isoindole-1,3(2H)-dione	524-38-9	C₈H₅NO₃	详情	详情
(II)	42514	2-butyn-1-ol	764-01-2	C₄H₆O	详情	详情
(III)	59686	2-(2-butynyloxy)-1H-isoindole-1,3(2H)-dione		C₁₂H₉NO₃	详情	详情
(IV)	59687	1-(aminooxy)-2-butyne; O-(2-butynyl)hydroxylamine		C₄H₇NO	详情	详情
(V)	16925	3-quinuclidinone; 1-azabicyclo[2.2.2]octan-3-one	1193-65-3	C₇H₁₁NO	详情	详情

合成路线3

该中间体在本合成路线中的序号：(IX)

Sulfonylation of methyl 5-bromo-3-methylanthranilate (I) with acid chloride (II) affords sulfonamide (III). Subsequent alkylation of the sulfonamide N of (III) with iodomethane and K2CO3 yields (IV). After protection of the phenolic hydroxyl group of (IV) as the silyl ether (V), benzylic halogenation with N-bromosuccinimide furnishes bromide (VI). Displacement of its benzylic bromide with 1-methylpiperazine (VII) occurs with concomitant desilylation to give (VIII). Mitsunobu coupling of phenol (VIII) with 2-butyn-1-ol (IX) leads to the propargyl ether (X). The methyl ester group of (X) is then hydrolyzed under alkaline conditions to furnish the carboxylic acid (XI).

参考文献中间体

合成目标

【1】 Levin, J.I.; Chen, J.M.; Du, M.T.; Nelson, F.C.; Killar, L.M.; Skala, S.; Sung, A.; Jin, G.; Cowling, R.; Barone, D.; March, C.J.; Mohler, K.M.; Black, R.A.; Skotnicki, J.S.; Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group. Bioorg Med Chem Lett 2002, 12, 8, 1199.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	60447	methyl 2-amino-5-bromo-3-methylbenzoate		C₉H₁₀BrNO₂	详情	详情
(II)	54660	4-hydroxybenzenesulfonyl chloride		C₆H₅ClO₃S	详情	详情
(III)	60448	methyl 5-bromo-2-{[(4-hydroxyphenyl)sulfonyl]amino}-3-methylbenzoate		C₁₅H₁₄BrNO₅S	详情	详情
(IV)	60449	methyl 5-bromo-2-[[(4-hydroxyphenyl)sulfonyl](methyl)amino]-3-methylbenzoate		C₁₆H₁₆BrNO₅S	详情	详情
(V)	60450	methyl 5-bromo-2-[[(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)sulfonyl](methyl)amino]-3-methylbenzoate		C₂₂H₃₀BrNO₅SSi	详情	详情
(VI)	60451	methyl 5-bromo-3-(bromomethyl)-2-[[(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)sulfonyl](methyl)amino]benzoate		C₂₂H₂₉Br₂NO₅SSi	详情	详情
(VII)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情
(VIII)	60452	methyl 5-bromo-2-[[(4-hydroxyphenyl)sulfonyl](methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoate		C₂₁H₂₆BrN₃O₅S	详情	详情
(IX)	42514	2-butyn-1-ol	764-01-2	C₄H₆O	详情	详情
(X)	60453	methyl 5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoate		C₂₅H₃₀BrN₃O₅S	详情	详情
(XI)	60454	5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoic acid		C₂₄H₂₈BrN₃O₅S	详情	详情

Extended Information