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【结 构 式】 
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【药物名称】 【化学名称】Quinuclidin-3-one O-2-butynyloxime 【CA登记号】 【 分 子 式 】C11H16N2O 【 分 子 量 】192.26297 |
【开发单位】DSO National Laboratories (Originator), National University of Singapore (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Muscarinic M1 Agonists |
合成路线1
N-(2-Butynyloxy)phthalimide (III) was obtained by the Mitsunobu coupling between 2-butyn-1-ol (II) and N-hydroxyphthalimide (I). Subsequent hydrazinolysis of (III) gave the O-alkynyl hydroxylamine (IV). This was finally condensed with quinuclidin-3-one (V) in methanol to furnish the corresponding oxime.
| 【1】 Go, M.-L.; Loke, W.-K.; Sim, M.-K.; Somanadhan, B.; Quinuclidinone O-alkynyloximes with muscarinic agonist activity. Bioorg Med Chem 2002, 10, 1, 207. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13505 | N-Hydroxyphthalimide; 2-Hydroxy-1H-isoindole-1,3(2H)-dione | 524-38-9 | C8H5NO3 | 详情 | 详情 |
| (II) | 42514 | 2-butyn-1-ol | 764-01-2 | C4H6O | 详情 | 详情 |
| (III) | 59686 | 2-(2-butynyloxy)-1H-isoindole-1,3(2H)-dione | C12H9NO3 | 详情 | 详情 | |
| (IV) | 59687 | 1-(aminooxy)-2-butyne; O-(2-butynyl)hydroxylamine | C4H7NO | 详情 | 详情 | |
| (V) | 16925 | 3-quinuclidinone; 1-azabicyclo[2.2.2]octan-3-one | 1193-65-3 | C7H11NO | 详情 | 详情 |
Extended Information