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【结 构 式】 
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【分子编号】42447 【品名】 【CA登记号】 |
【 分 子 式 】C81H137ClO21Si3 【 分 子 量 】1566.67538 【元素组成】C 62.1% H 8.81% Cl 2.26% O 21.45% Si 5.38% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LXXXVII)Synthesis of the target 213774: The Wittig condensation of the intermediate aldehyde (L) with the intermediate phosphonium iodide (LXXXV) by means of LDA in THF/HMPA gives the adduct (LXXXVI). Cleavage of the Mpm protecting groups and simultaneous hydrolysis of the methyl ketal group with DDQ, followed by KF-induced elimination of the silyl ester protecting group and macrolactonization under Yamaguchi conditions, afforded macrolactone (LXXXVII). Finally, this compound is desilylated with HF/pyridine in THF.
| 【1】 Hayward, M.M.; et al.; Total synthesis of altohyrtin A (spongistatin 1): Part 2. Angew Chem. Int Ed Engl 1998, 37, 1-2, 192. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (L) | 42411 | tert-butyl(diphenyl)silyl 2-[(2R,4S,6R,8S,10S)-4-(acetoxy)-8-(2-[(1R,2S,3S)-2-(acetoxy)-5-[(2S,4S,6S,8R)-8-formyl-4-methoxy-1,7-dioxaspiro[5.5]undec-2-yl]-1,3-dimethyl-4-oxopentyl]-2-propenyl)-10-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-2-yl]a | C53H74O14Si | 详情 | 详情 | |
| (LXXXV) | 42445 | (4-[(2R,3S,4S,6R)-4-[[tert-butyl(dimethyl)silyl]oxy]-6-[(S)-[(2R,3R,4R,5S,6R)-6-((4S,5E)-4-[[tert-butyl(dimethyl)silyl]oxy]-7-chloro-2-methylene-5,7-octadienyl)-4,5-bis[(4-methoxybenzyl)oxy]-3-methyltetrahydro-2H-pyran-2-yl](hydroxy)methyl]-6-methox | C73H103ClIO10PSi2 | 详情 | 详情 | |
| (LXXXVI) | 42446 | C114H175ClO24Si4 | 详情 | 详情 | ||
| (LXXXVII) | 42447 | C81H137ClO21Si3 | 详情 | 详情 |
Extended Information