• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】42446

【品名】 

【CA登记号】

【 分 子 式 】C114H175ClO24Si4

【 分 子 量 】2077.4238

【元素组成】C 65.91% H 8.49% Cl 1.71% O 18.48% Si 5.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(LXXXVI)

Synthesis of the target 213774: The Wittig condensation of the intermediate aldehyde (L) with the intermediate phosphonium iodide (LXXXV) by means of LDA in THF/HMPA gives the adduct (LXXXVI). Cleavage of the Mpm protecting groups and simultaneous hydrolysis of the methyl ketal group with DDQ, followed by KF-induced elimination of the silyl ester protecting group and macrolactonization under Yamaguchi conditions, afforded macrolactone (LXXXVII). Finally, this compound is desilylated with HF/pyridine in THF.

1 Hayward, M.M.; et al.; Total synthesis of altohyrtin A (spongistatin 1): Part 2. Angew Chem. Int Ed Engl 1998, 37, 1-2, 192.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(L) 42411 tert-butyl(diphenyl)silyl 2-[(2R,4S,6R,8S,10S)-4-(acetoxy)-8-(2-[(1R,2S,3S)-2-(acetoxy)-5-[(2S,4S,6S,8R)-8-formyl-4-methoxy-1,7-dioxaspiro[5.5]undec-2-yl]-1,3-dimethyl-4-oxopentyl]-2-propenyl)-10-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-2-yl]a C53H74O14Si 详情 详情
(LXXXV) 42445 (4-[(2R,3S,4S,6R)-4-[[tert-butyl(dimethyl)silyl]oxy]-6-[(S)-[(2R,3R,4R,5S,6R)-6-((4S,5E)-4-[[tert-butyl(dimethyl)silyl]oxy]-7-chloro-2-methylene-5,7-octadienyl)-4,5-bis[(4-methoxybenzyl)oxy]-3-methyltetrahydro-2H-pyran-2-yl](hydroxy)methyl]-6-methox C73H103ClIO10PSi2 详情 详情
(LXXXVI) 42446   C114H175ClO24Si4 详情 详情
(LXXXVII) 42447   C81H137ClO21Si3 详情 详情
Extended Information