2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetohydrazide -Drug Synthesis Database

【结构式】

【分子编号】42233

【品名】2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetohydrazide

【CA登记号】

【分子式】C₁₂H₁₁N₃O₃

【分子量】245.23776

【元素组成】C 58.77% H 4.52% N 17.13% O 19.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The title hydrazone was prepared by condensation of doxorubicin hydrochloride (I) with 4-maleimidophenylacetic acid hydrazide trifluoroacetate salt (II) in methanol.

参考文献中间体

合成目标

【1】 Kratz, F.; Schumacher, P.; Beyer, U.; Zahn, H.; Unger, C.; Kruger, M.; Synthesis and stability of four maleimide derivatives of the anticancer drug doxorubicin for the preparation of cemoinmunoconjugates. Chem Pharm Bull 1997, 45, 2, 399-401.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11675	(8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione		C₂₇H₂₉NO₁₁	详情	详情
(II)	42233	2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetohydrazide		C₁₂H₁₁N₃O₃	详情	详情

Extended Information