|
【结 构 式】 
|
【药物名称】 【化学名称】N'-[1-[4(S)-(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyloxy)-2(S),5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-2-yl]-2-hydroxyethylidene]-2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetohydrazide hydrochloride 【CA登记号】202407-74-7 【 分 子 式 】C39H39ClN4O13 【 分 子 量 】807.21768 |
【开发单位】Universität Freiburg (Originator) 【药理作用】Antibiotics and Alkaloids, Antineoplastic Antibiotics, Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, ONCOLYTIC DRUGS |
合成路线1
The title hydrazone was prepared by condensation of doxorubicin hydrochloride (I) with 4-maleimidophenylacetic acid hydrazide trifluoroacetate salt (II) in methanol.
| 【1】 Kratz, F.; Schumacher, P.; Beyer, U.; Zahn, H.; Unger, C.; Kruger, M.; Synthesis and stability of four maleimide derivatives of the anticancer drug doxorubicin for the preparation of cemoinmunoconjugates. Chem Pharm Bull 1997, 45, 2, 399-401. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11675 | (8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione | C27H29NO11 | 详情 | 详情 | |
| (II) | 42233 | 2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetohydrazide | C12H11N3O3 | 详情 | 详情 |
Extended Information