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【结 构 式】

【分子编号】42144

【品名】 

【CA登记号】

【 分 子 式 】C100H171ClN34O24S

【 分 子 量 】2301.1912

【元素组成】C 52.19% H 7.49% Cl 1.54% N 20.69% O 16.69% S 1.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XX)

Simultaneous coupling of five N-Boc-arginin (XIX) residues to the free amino groups of the peptide template (XVIII), followed by acid deprotection of the Boc groups, furnished (XX). To this were assembled five N-Boc-proline residues (XXI) to provide, after acid deprotection, resin (XXII). Then, reductive condensation with Boc-protected lysinal (XXIII) furnished the protected pseudopeptide adduct (XXIV). Finally, simultaneous cleavage from the resin and removal of protecting groups was effected by treatment with anhydrous hydrogen fluoride.

1 Callebaut, C.; et al.; Inhibition of HIV infection by pseudopeptides blocking viral envelope glycoprotein-mediated membrane fusion and cell death. Virology 1996, 218, 1, 181.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XVIII) 42143 (3S,6S,9R,15R)-3,9-bis(4-aminobutyl)-1-[(2S)-1-((5S,8S)-5-(4-aminobutyl)-16-(4-chlorophenyl)-8-[[(2S)-2,6-diaminohexanoyl]amino]-4,7,14-trioxo-15-oxa-3,6,13-triazahexadec-1-anoyl)pyrrolidinyl]-6-[3-(cyclohexyloxy)-3-oxopropyl]-15-[[(4-methylbenzyl)s C70H111ClN14O15S 详情 详情
(XIX) 14073 (2S)-5-[[Amino(imino)methyl]amino]-2-[(tert-butoxycarbonyl)amino]pentanoic acid 13726-76-6 C11H22N4O4 详情 详情
(XX) 42144   C100H171ClN34O24S 详情 详情
(XXI) 16734 (2S)-1-(tert-butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic acid; N-alpha-t-BOC-L-proline; (2S)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid C10H17NO4 详情 详情
(XXII) 42145   C81H126ClN19O17SArg4Pro4 详情 详情
(XXIII) 42146 tert-butyl (1S)-5-[(tert-butoxycarbonyl)amino]-1-formylpentylcarbamate C16H30N2O5 详情 详情
(XXIV) 42147   C205H350ClN53O50S 详情 详情
Extended Information