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【结 构 式】

【药物名称】5[Kpsi(CH2N)PR]-TASP, HB-19

【化学名称】N2,N6-[H-L-Lys[psi(CH2N)]L-Pro-L-Arg]-L-Lys-L-Lys-N6-[H-L-Lys[psi(CH2N)]L-Pro-L-Arg]-L-Lys-Gly-L-Pro-N6-[H-L-Lys[psi(CH2N)]L-Pro-L-Arg]-L-Lys-L-Glu-N6-[H-L-Lys[psi(CH2N)]L-Pro-L-Arg]-L-Lys-Gly-L-Cys-OH
      N2,N6-Bis[1-[(2S)-2,6-diaminohexyl]-L-prolyl-L-arginyl]-L-lysyl-L-lysyl-N6-[1-[(2S)-2,6-diaminohexyl]-L-prolyl-L-arginyl]-L-lysylglycyl-L-prolyl-N6-[1-[(2S)-2,6-diaminohexyl]-L-prolyl-L-arginyl]-L-lysyl-L-alpha-glutamyl-N6-[1-[(2S)-2,6-diaminohexyl]-L-prolyl-L-arginyl]-L-lysylglycyl-L-cysteine

【CA登记号】175297-53-7

【 分 子 式 】C132H252N50O23S

【 分 子 量 】2939.86544

【开发单位】CNRS (Originator), Institut Pasteur (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY

合成路线1

The title compound was obtained by solid-phase peptide synthesis starting from N-Boc-S-(4-methylbenzyl)cysteine linked to PAM resin (I). The protected peptide template (XVII) was synthesized by sequential coupling-deprotection cycles using the appropriate combination of either Boc- or Fmoc- N-alpha-protected amino acids. The following side-chain-protected amino acid residues were assembled: Gly (III), Lys(Boc) (V), Glu(cyclohexyl ester) (VII), Lys(Boc) (V), Pro (X), Gly (III), Lys(Boc) (V), Lys(chlorobenzyloxycarbonyl) (XIV) and Lys(Boc) (XVI) to produce the peptide resins (IV), (VI), (VIII), (IX), (XI), (XII), (XIII), (XV) and (XVII), respectively. Subsequent removal of the N-terminal and the four side-chain Boc protecting groups by means of trifluoroacetic acid yielded the peptide resin (XVIII).

1 Callebaut, C.; et al.; Inhibition of HIV infection by pseudopeptides blocking viral envelope glycoprotein-mediated membrane fusion and cell death. Virology 1996, 218, 1, 181.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 42129 (2R)-2-[(tert-butoxycarbonyl)amino]-3-[(4-methylbenzyl)sulfanyl]propionic acid C16H23NO4S 详情 详情
(II) 42130 (2R)-2-amino-3-[(4-methylbenzyl)sulfanyl]propionic acid 42294-52-0 C11H15NO2S 详情 详情
(III) 42131 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid 29022-11-5 C17H15NO4 详情 详情
(IV) 42132 (2R)-2-[(2-aminoacetyl)amino]-3-[(4-methylbenzyl)sulfanyl]propionic acid C13H18N2O3S 详情 详情
(V) 18854 (2S)-6-[(tert-butoxycarbonyl)amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexanoic acid C26H32N2O6 详情 详情
(VI) 42133 (10S,16R)-10-amino-2,2-dimethyl-16-[[(4-methylbenzyl)sulfanyl]methyl]-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oic acid C24H38N4O6S 详情 详情
(VII) 42134 (2S)-5-(cyclohexyloxy)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-oxopentanoic acid 150047-85-1 C26H29NO6 详情 详情
(VIII) 42135 (10R,16R)-10-[(3S)-3-amino-6-(cyclohexyloxy)-2,6-dioxohexyl]-2,2-dimethyl-16-[[(4-methylbenzyl)sulfanyl]methyl]-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oic acid C36H56N4O9S 详情 详情
(IX) 42136 (10S,13S,16R,22R)-10-amino-16-[4-[(tert-butoxycarbonyl)amino]butyl]-13-[3-(cyclohexyloxy)-3-oxopropyl]-2,2-dimethyl-22-[[(4-methylbenzyl)sulfanyl]methyl]-4,11,14,17,20-pentaoxo-3-oxa-5,12,18,21-tetraazatricosan-23-oic acid C47H76N6O12S 详情 详情
(X) 34762 (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-pyrrolidinecarboxylic acid 71989-31-6 C20H19NO4 详情 详情
(XI) 42137 (10S,13S,16R,22R)-16-[4-[(tert-butoxycarbonyl)amino]butyl]-13-[3-(cyclohexyloxy)-3-oxopropyl]-2,2-dimethyl-22-[[(4-methylbenzyl)sulfanyl]methyl]-4,11,14,17,20-pentaoxo-10-[[(2S)pyrrolidinylcarbonyl]amino]-3-oxa-5,12,18,21-tetraazatricosan-23-oic acid C52H83N7O13S 详情 详情
(XII) 42138 (10S,13S,16R,22R)-10-([[(2S)-1-(2-aminoacetyl)pyrrolidinyl]carbonyl]amino)-16-[4-[(tert-butoxycarbonyl)amino]butyl]-13-[3-(cyclohexyloxy)-3-oxopropyl]-2,2-dimethyl-22-[[(4-methylbenzyl)sulfanyl]methyl]-4,11,14,17,20-pentaoxo-3-oxa-5,12,18,21-tetraaz C54H86N8O14S 详情 详情
(XIII) 42139 (10S,13S,16R,22R)-10-[([(2S)-1-[2-([(2S)-2-amino-6-[(tert-butoxycarbonyl)amino]hexanoyl]amino)acetyl]pyrrolidinyl]carbonyl)amino]-16-[4-[(tert-butoxycarbonyl)amino]butyl]-13-[3-(cyclohexyloxy)-3-oxopropyl]-2,2-dimethyl-22-[[(4-methylbenzyl)sulfanyl] C65H106N10O17S 详情 详情
(XIV) 42140 (2S)-6-([[(4-chlorobenzyl)oxy]carbonyl]amino)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexanoic acid C29H29ClN2O6 详情 详情
(XV) 42141 (10S,13S,16R,22R)-10-[([(2S)-1-[(5S,8S)-8-amino-5-[4-[(tert-butoxycarbonyl)amino]butyl]-16-(4-chlorophenyl)-4,7,14-trioxo-15-oxa-3,6,13-triazahexadec-1-anoyl]pyrrolidinyl]carbonyl)amino]-16-[4-[(tert-butoxycarbonyl)amino]butyl]-13-[3-(cyclohexyloxy) C79H123ClN12O20S 详情 详情
(XVI) 37991 (2S)-2,6-bis[(tert-butoxycarbonyl)amino]hexanoic acid 2483-46-7 C16H30N2O6 详情 详情
(XVII) 42142 (10S,13S,16R,22R)-10-[[((2S)-1-[(5S,8S,11S)-11-[(tert-butoxycarbonyl)amino]-5-[4-[(tert-butoxycarbonyl)amino]butyl]-8-[4-([[(4-chlorobenzyl)oxy]carbonyl]amino)butyl]-19,19-dimethyl-4,7,10,17-tetraoxo-18-oxa-3,6,9,16-tetraazaicos-1-anoyl]pyrrolidinyl C95H151ClN14O25S 详情 详情
(XVIII) 42143 (3S,6S,9R,15R)-3,9-bis(4-aminobutyl)-1-[(2S)-1-((5S,8S)-5-(4-aminobutyl)-16-(4-chlorophenyl)-8-[[(2S)-2,6-diaminohexanoyl]amino]-4,7,14-trioxo-15-oxa-3,6,13-triazahexadec-1-anoyl)pyrrolidinyl]-6-[3-(cyclohexyloxy)-3-oxopropyl]-15-[[(4-methylbenzyl)s C70H111ClN14O15S 详情 详情

合成路线2

Simultaneous coupling of five N-Boc-arginin (XIX) residues to the free amino groups of the peptide template (XVIII), followed by acid deprotection of the Boc groups, furnished (XX). To this were assembled five N-Boc-proline residues (XXI) to provide, after acid deprotection, resin (XXII). Then, reductive condensation with Boc-protected lysinal (XXIII) furnished the protected pseudopeptide adduct (XXIV). Finally, simultaneous cleavage from the resin and removal of protecting groups was effected by treatment with anhydrous hydrogen fluoride.

1 Callebaut, C.; et al.; Inhibition of HIV infection by pseudopeptides blocking viral envelope glycoprotein-mediated membrane fusion and cell death. Virology 1996, 218, 1, 181.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XVIII) 42143 (3S,6S,9R,15R)-3,9-bis(4-aminobutyl)-1-[(2S)-1-((5S,8S)-5-(4-aminobutyl)-16-(4-chlorophenyl)-8-[[(2S)-2,6-diaminohexanoyl]amino]-4,7,14-trioxo-15-oxa-3,6,13-triazahexadec-1-anoyl)pyrrolidinyl]-6-[3-(cyclohexyloxy)-3-oxopropyl]-15-[[(4-methylbenzyl)s C70H111ClN14O15S 详情 详情
(XIX) 14073 (2S)-5-[[Amino(imino)methyl]amino]-2-[(tert-butoxycarbonyl)amino]pentanoic acid 13726-76-6 C11H22N4O4 详情 详情
(XX) 42144   C100H171ClN34O24S 详情 详情
(XXI) 16734 (2S)-1-(tert-butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic acid; N-alpha-t-BOC-L-proline; (2S)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid C10H17NO4 详情 详情
(XXII) 42145   C81H126ClN19O17SArg4Pro4 详情 详情
(XXIII) 42146 tert-butyl (1S)-5-[(tert-butoxycarbonyl)amino]-1-formylpentylcarbamate C16H30N2O5 详情 详情
(XXIV) 42147   C205H350ClN53O50S 详情 详情
Extended Information