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【结 构 式】 
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【分子编号】42017 【品名】(5R)-5-isopropyl-1-[(4-methylphenyl)sulfonyl]-1,2-azaborolidin-4-one 【CA登记号】 |
【 分 子 式 】C13H18BNO3S 【 分 子 量 】279.16786 【元素组成】C 55.93% H 6.5% B 3.87% N 5.02% O 17.19% S 11.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Synthesis of intermediate (V): The condensation of octanal (II) with the trimethylsilyl ether of the enol form of methyl isobutyrate (I) by means of the chiral oxazaborolidinone catalyst (III) in THF gives 3(S)-hydroxy-2,2-dimethyldecanoic acid methyl ester (IV), which is hydrolyzed with NaOH in methanol/water to yield the acid intermediate (V).
| 【1】 Yokokawa, F.; et al.; Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete. Tetrahedron 2000, 56, 19, 3027. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42016 | 1-Methoxy-2-methyl-1-(trimethylsiloxy)propene;1-Methoxy-2,2-dimethyl-1-(trimethylsiloxy)ethene;1-Methoxy-1-(trimethylsilyloxy)-2-methylpropene;[(1-methoxy-2-methyl-1-propenyl)oxy](trimethyl)silane; 1-methoxy-2-methyl-1-propenyl trimethylsilyl ether ;dimethylketene methyl trimethylsilyl acetal | 31469-15-5 | C8H18O2Si | 详情 | 详情 |
| (II) | 25714 | octanal | 124-13-0 | C8H16O | 详情 | 详情 |
| (III) | 42017 | (5R)-5-isopropyl-1-[(4-methylphenyl)sulfonyl]-1,2-azaborolidin-4-one | C13H18BNO3S | 详情 | 详情 | |
| (IV) | 42018 | methyl (3S)-3-hydroxy-2,2-dimethyldecanoate | C13H26O3 | 详情 | 详情 | |
| (V) | 42019 | (3S)-3-hydroxy-2,2-dimethyldecanoic acid | C12H24O3 | 详情 | 详情 |
Extended Information