1-isocyanato-2-methoxybenzene; 2-methoxyphenyl isocyanate -Drug Synthesis Database

【结构式】

【分子编号】41953

【品名】1-isocyanato-2-methoxybenzene; 2-methoxyphenyl isocyanate

【CA登记号】700-87-8

【分子式】C₈H₇NO₂

【分子量】149.14912

【元素组成】C 64.42% H 4.73% N 9.39% O 21.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The amide anion obtained from 2-aminobenzonitrile (I) and NaH in THF was added to 3-cyanopyridine (II) yielding 2-(3-pyridyl)-4-aminoquinazoline (III). This was then condensed with 2-methoxyphenyl isocyanate (IV) to furnish the title urea.

参考文献中间体

合成目标

【1】 Frijtag von Drabbe Künzel, J.; van Muijlwijk-Koezen, J.E.; de Groote, M.; van der Goot, H.; Menge, W.M.P.B.; Ijzerman, A.P.; Timmerman, H.; Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J Med Chem 2000, 43, 11, 2227.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19493	2-aminobenzonitrile	1885-29-6	C₇H₆N₂	详情	详情
(II)	14062	Nicotinonitrile; 3-Cyanopyridine	100-54-9	C₆H₄N₂	详情	详情
(III)	41952	2-(3-pyridinyl)-4-quinazolinamine; 2-(3-pyridinyl)-4-quinazolinylamine		C₁₃H₁₀N₄	详情	详情
(IV)	41953	1-isocyanato-2-methoxybenzene; 2-methoxyphenyl isocyanate	700-87-8	C₈H₇NO₂	详情	详情

Extended Information