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【结 构 式】 
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【药物名称】VUF-5574 【化学名称】N-(2-Methoxyphenyl)-N'-[2-(3-pyridinyl)quinazolin-4-yl]urea 【CA登记号】 【 分 子 式 】C21H17N5O2 【 分 子 量 】371.40194 |
【开发单位】Vrije Universiteit (Originator) 【药理作用】Pharmacological Tools, Adenosine A3 Antagonists |
合成路线1
The amide anion obtained from 2-aminobenzonitrile (I) and NaH in THF was added to 3-cyanopyridine (II) yielding 2-(3-pyridyl)-4-aminoquinazoline (III). This was then condensed with 2-methoxyphenyl isocyanate (IV) to furnish the title urea.
| 【1】 Frijtag von Drabbe Künzel, J.; van Muijlwijk-Koezen, J.E.; de Groote, M.; van der Goot, H.; Menge, W.M.P.B.; Ijzerman, A.P.; Timmerman, H.; Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J Med Chem 2000, 43, 11, 2227. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19493 | 2-aminobenzonitrile | 1885-29-6 | C7H6N2 | 详情 | 详情 |
| (II) | 14062 | Nicotinonitrile; 3-Cyanopyridine | 100-54-9 | C6H4N2 | 详情 | 详情 |
| (III) | 41952 | 2-(3-pyridinyl)-4-quinazolinamine; 2-(3-pyridinyl)-4-quinazolinylamine | C13H10N4 | 详情 | 详情 | |
| (IV) | 41953 | 1-isocyanato-2-methoxybenzene; 2-methoxyphenyl isocyanate | 700-87-8 | C8H7NO2 | 详情 | 详情 |
Extended Information