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【结 构 式】 
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【分子编号】41636 【品名】(2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy]tetrahydro-2H-pyran-2,3,4-triol 【CA登记号】 |
【 分 子 式 】C12H22O11 【 分 子 量 】342.30008 【元素组成】C 42.11% H 6.48% O 51.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Reduction of carboxylic acid (Trolox) (I) with LiAlH4 in refluxing diethyl ether affords alcohol (TM) (II). Reaction of (II) in DMSO with maltose (III) and alpha-glucosidase in potassium phosphate buffer yields the final product.
| 【1】 Murase, H.; et al.; Antioxidant activity of a novel vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol. Free Radical Biol Med 1998, 24, 2, 217. |
| 【2】 Murase, H.; et al.; Synthesis of a novel vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, by alpha-glucosidase-catalyzed transglycosylation. Lipids 1997, 32, 1, 73. |
| 【3】 Murase, H.; Tsujii, T.; Kunieda, T. (CCI Corporation); Chromanol glycoside and method for production thereof. US 5478812 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21255 | Trolox; Trolox C; 6-hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid | 53188-07-1 | C14H18O4 | 详情 | 详情 |
| (II) | 21256 | 2-(hydroxymethyl)-2,5,7,8-tetramethyl-6-chromanol | C14H20O3 | 详情 | 详情 | |
| (III) | 41636 | (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy]tetrahydro-2H-pyran-2,3,4-triol | C12H22O11 | 详情 | 详情 |
Extended Information