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【结 构 式】 
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【分子编号】41625 【品名】3-[(E)-1,3-benzodioxol-5-ylmethylidene]-2-pyrrolidinone 【CA登记号】 |
【 分 子 式 】C12H11NO3 【 分 子 量 】217.22428 【元素组成】C 66.35% H 5.1% N 6.45% O 22.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of piperonal (I) with N-acetyl-2-pyrrolidone (II) in the presence of NaH in THF afforded the benzylidene pyrrolidone (III). The title formamide was then obtained upon refluxing of (III) with formic acid with azeotropical removal of water.
| 【1】 Fuse, Y.; Kitahara, M.; Yamamoto, K.; Yokota, S.; Morikawa, S. (Kaneka Corp.); Heat shock factor activity inhibitors. EP 0995745; WO 9900382 . |
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