【结 构 式】 |
【药物名称】KNK-437 【化学名称】3-[(E)-1,3-Benzodioxol-5-ylmethylene]-2-oxopyrrolidine-1-carbaldehyde 【CA登记号】218924-25-5 【 分 子 式 】C13H11NO4 【 分 子 量 】245.23692 |
【开发单位】Kaneka (Originator) 【药理作用】Antineoplastic Enhancing Agents, Modulators of the Therapeutic Activity of Antineoplastic Agents, ONCOLYTIC DRUGS |
合成路线1
Condensation of piperonal (I) with N-acetyl-2-pyrrolidone (II) in the presence of NaH in THF afforded the benzylidene pyrrolidone (III). The title formamide was then obtained upon refluxing of (III) with formic acid with azeotropical removal of water.
【1】 Fuse, Y.; Kitahara, M.; Yamamoto, K.; Yokota, S.; Morikawa, S. (Kaneka Corp.); Heat shock factor activity inhibitors. EP 0995745; WO 9900382 . |
Extended Information