4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】41440

【品名】4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

【CA登记号】

【分子式】C₉H₉BrN₂O₃

【分子量】273.08614

【元素组成】C 39.58% H 3.32% Br 29.26% N 10.26% O 17.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Coupling of alpha-bromoacrylic acid (V) with 1-methyl-4-aminopyrrole-2-carboxylic acid (VI) using DCC gave amide (VII). Subsequent treatment with thionyl chloride furnished acid chloride (VIII).

参考文献中间体

合成目标

【1】 Cozzi, P.; Beria, I.; Biasoli, G.; Caldarelli, M.; Capolongo, L.; Franzetti, C. (Pharmacia & Upjohn AB); Acryloyl substd. distamycin derivs., process for preparing them, and their use as antitumor and antiviral agents. WO 9804524 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	41438	2-bromoacrylic acid	10443-65-9	C₃H₃BrO₂	详情	详情
(VI)	41439	4-amino-1-methyl-1H-pyrrole-2-carboxylic acid		C₆H₈N₂O₂	详情	详情
(VII)	41440	4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid		C₉H₉BrN₂O₃	详情	详情
(VIII)	41441	4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carbonyl chloride		C₉H₈BrClN₂O₂	详情	详情

Extended Information