【结 构 式】 |
【分子编号】41438 【品名】2-bromoacrylic acid 【CA登记号】10443-65-9 |
【 分 子 式 】C3H3BrO2 【 分 子 量 】150.95962 【元素组成】C 23.87% H 2% Br 52.93% O 21.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)Coupling of alpha-bromoacrylic acid (V) with 1-methyl-4-aminopyrrole-2-carboxylic acid (VI) using DCC gave amide (VII). Subsequent treatment with thionyl chloride furnished acid chloride (VIII).
【1】 Cozzi, P.; Beria, I.; Biasoli, G.; Caldarelli, M.; Capolongo, L.; Franzetti, C. (Pharmacia & Upjohn AB); Acryloyl substd. distamycin derivs., process for preparing them, and their use as antitumor and antiviral agents. WO 9804524 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 41438 | 2-bromoacrylic acid | 10443-65-9 | C3H3BrO2 | 详情 | 详情 |
(VI) | 41439 | 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid | C6H8N2O2 | 详情 | 详情 | |
(VII) | 41440 | 4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid | C9H9BrN2O3 | 详情 | 详情 | |
(VIII) | 41441 | 4-[(2-bromoacryloyl)amino]-1-methyl-1H-pyrrole-2-carbonyl chloride | C9H8BrClN2O2 | 详情 | 详情 |
Extended Information