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【结 构 式】 
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【分子编号】40880 【品名】tert-butyl 3-[[methoxy(methyl)amino]carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate 【CA登记号】 |
【 分 子 式 】C17H24N2O4 【 分 子 量 】320.38864 【元素组成】C 63.73% H 7.55% N 8.74% O 19.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)The intermediate 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carbaldehyde (V) has been obtained as follows: The reaction of 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (XI) with N,O-dimethylhydroxylamine (XII) by means of BOP gives the corresponding N-methoxy-N-methylamide (XIII), which the reduced to the target aldehyde (V) with LiAlH4.
| 【1】 Schiller, P. (AstraZeneca plc); New peptides. EP 0678099; JP 1996505386; WO 9415959 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 40873 | tert-butyl 3-formyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C15H19NO3 | 详情 | 详情 | |
| (XI) | 40879 | 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid | C15H19NO4 | 详情 | 详情 | |
| (XII) | 13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 |
| (XIII) | 40880 | tert-butyl 3-[[methoxy(methyl)amino]carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C17H24N2O4 | 详情 | 详情 |
Extended Information