7-chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one -Drug Synthesis Database

【结构式】

【分子编号】40454

【品名】7-chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

【CA登记号】846-50-4

【分子式】C₁₆H₁₃ClN₂O₂

【分子量】300.7442

【元素组成】C 63.9% H 4.36% Cl 11.79% N 9.31% O 10.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with phenyl chlorocarbonate (II) in pyridine yields 7-chloro-1,3-dihydro-3-phenoxycarbonyl-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (III), m.p. 176-8 C, which is then condensed with dimethylamine.

参考文献中间体

合成目标

【1】 Castaner, J.; Bundgaard, H.; Camazepam. Drugs Fut 1976, 1, 10, 458.
【2】 Ferrrari, G.; Casagrande, C.; 1,4-Benzodiazepine derivatives. DE 2142181; ES 394484; FR 2103475; GB 1327930 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40454	7-chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one	846-50-4	C₁₆H₁₃ClN₂O₂	详情	详情
(II)	13580	1-[(Chlorocarbonyl)oxy]benzene; phenyl chloroformate	1885-14-9	C₇H₅ClO₂	详情	详情
(III)	40455	7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl phenyl carbonate		C₂₃H₁₇ClN₂O₄	详情	详情
(IV)	19443	N-methylmethanamine; N,N-dimethylamine	124-40-3	C₂H₇N	详情	详情

Extended Information