【结 构 式】 |
【药物名称】Camazepam, Albego 【化学名称】N,N-Dimethylcarbamic acid 7-chloro-3-hydroxy-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl ester 【CA登记号】36104-80-0 【 分 子 式 】C19H18ClN3O3 【 分 子 量 】371.82661 |
【开发单位】Boehringer Ingelheim (Originator) 【药理作用】Anxiolytics, PSYCHOPHARMACOLOGIC DRUGS, Benzodiazepines, GABA(A) BZ Site Receptor Agonists |
合成路线1
The condensation of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with phenyl chlorocarbonate (II) in pyridine yields 7-chloro-1,3-dihydro-3-phenoxycarbonyl-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (III), m.p. 176-8 C, which is then condensed with dimethylamine.
【1】 Castaner, J.; Bundgaard, H.; Camazepam. Drugs Fut 1976, 1, 10, 458. |
【2】 Ferrrari, G.; Casagrande, C.; 1,4-Benzodiazepine derivatives. DE 2142181; ES 394484; FR 2103475; GB 1327930 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 40454 | 7-chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | 846-50-4 | C16H13ClN2O2 | 详情 | 详情 |
(II) | 13580 | 1-[(Chlorocarbonyl)oxy]benzene; phenyl chloroformate | 1885-14-9 | C7H5ClO2 | 详情 | 详情 |
(III) | 40455 | 7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl phenyl carbonate | C23H17ClN2O4 | 详情 | 详情 | |
(IV) | 19443 | N-methylmethanamine; N,N-dimethylamine | 124-40-3 | C2H7N | 详情 | 详情 |
Extended Information