2-cyclopentylphenyl 2-oxiranylmethyl ether; 2-[(2-cyclopentylphenoxy)methyl]oxirane -Drug Synthesis Database

【结构式】

【分子编号】40453

【品名】2-cyclopentylphenyl 2-oxiranylmethyl ether; 2-[(2-cyclopentylphenoxy)methyl]oxirane

【CA登记号】28163-40-8

【分子式】C₁₄H₁₈O₂

【分子量】218.29572

【元素组成】C 77.03% H 8.31% O 14.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 2-cyclopentylphenol (I) with epichlorhydrin (II) in a basic medium yields 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane (III), which is the condensed with tert-butylamine (IV) in hot ethanol.

参考文献中间体

合成目标

【1】 Ruschig, H.; et al.; ZA 6807915 .
【2】 Castaner, J.; Weetman, D.F.; Penbutolol. Drugs Fut 1976, 1, 10, 494.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40452	2-cyclopentylphenol		C₁₁H₁₄O	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	40453	2-cyclopentylphenyl 2-oxiranylmethyl ether; 2-[(2-cyclopentylphenoxy)methyl]oxirane	28163-40-8	C₁₄H₁₈O₂	详情	详情
(IV)	17895	2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine	75-64-9	C₄H₁₁N	详情	详情

Extended Information