|
【结 构 式】 
|
【药物名称】Penbutolol sulfate, Hoe-893d, Hoe-39893d, Levatol, Betapressin 【化学名称】(S)-1-(2-Cyclopentylphenoxy)-3-(1,1-dimethylethylamino)-2-propanol sulfate (2:1) 【CA登记号】38363-32-5, 38363-40-5 (free base) 【 分 子 式 】C18H31NO6S 【 分 子 量 】389.51487 |
【开发单位】Aventis Behring (Originator), Aventis Pharma (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, beta-Adrenoceptor Antagonists |
合成路线1
The reaction of 2-cyclopentylphenol (I) with epichlorhydrin (II) in a basic medium yields 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane (III), which is the condensed with tert-butylamine (IV) in hot ethanol.
| 【1】 Ruschig, H.; et al.; ZA 6807915 . |
| 【2】 Castaner, J.; Weetman, D.F.; Penbutolol. Drugs Fut 1976, 1, 10, 494. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40452 | 2-cyclopentylphenol | C11H14O | 详情 | 详情 | |
| (II) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
| (III) | 40453 | 2-cyclopentylphenyl 2-oxiranylmethyl ether; 2-[(2-cyclopentylphenoxy)methyl]oxirane | 28163-40-8 | C14H18O2 | 详情 | 详情 |
| (IV) | 17895 | 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine | 75-64-9 | C4H11N | 详情 | 详情 |
Extended Information