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【结 构 式】 
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【分子编号】40411 【品名】1-(3-fluorophenyl)-1-ethanone 【CA登记号】455-36-7 |
【 分 子 式 】C8H7FO 【 分 子 量 】138.1413832 【元素组成】C 69.56% H 5.11% F 13.75% O 11.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)By condensation of 3-fluoroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.
| 【1】 Hind, S.L.; Janssen, M.; Reinhard, J.F. Jr.; Drysdale, M.J.; Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. J Med Chem 2000, 43, 1, 123. |
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