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【结 构 式】 
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【药物名称】 【化学名称】4-(3-Fluorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester 【CA登记号】 【 分 子 式 】C11H9FO4 【 分 子 量 】224.19038 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Kynureninase Inhibitors |
合成路线1
By condensation of 3-fluoroacetophenone (I) with dimethyl oxalate (II) by means of NaOMe in methanol.
| 【1】 Hind, S.L.; Janssen, M.; Reinhard, J.F. Jr.; Drysdale, M.J.; Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. J Med Chem 2000, 43, 1, 123. |
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