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【结 构 式】 
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【分子编号】40234 【品名】 【CA登记号】 |
【 分 子 式 】C82H106N10O26 【 分 子 量 】1647.79544 【元素组成】C 59.77% H 6.48% N 8.5% O 25.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)The pentaamino compound (XVIII) was coupled with N-(benzyloxycarbonyl)glycine (XIX) employing EDC and HOBt to afford penta amide (XX). The carbobenzoy protecting groups of (XX) were then removed by hydrogenation over PtO2 to give (XXI). Finally, installation of the guanidino groups in (XXI) was carried out by condensation with N,N'-di(carbobenzoxy)-S-methylisothiourea (XXII), followed by hydrogenolysis of the carbobenzoxy groups.
| 【1】 Xuereb, H.; et al.; Design of an Oligosaccharide Scaffold that binds in the minor groove of DNA. J Am Chem Soc 2000, 122, 9, 1883-90. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVIII) | 40234 | C82H106N10O26 | 详情 | 详情 | ||
| (XIX) | 17764 | N-Carbobenzyloxyglycine; 2-[[(benzyloxy)carbonyl]amino]acetic acid | 1138-80-3 | C10H11NO4 | 详情 | 详情 |
| (XX) | 40235 | C42H76N10O16 | 详情 | 详情 | ||
| (XXI) | 40236 | ethyl (2E,4E)-2,4-hexadienoate | 2396-84-1 | C8H12O2 | 详情 | 详情 |
| (XXII) | 32861 | benzyl (E)-[[(benzyloxy)carbonyl]amino](methylsulfanyl)methylidenecarbamate | C18H18N2O4S | 详情 | 详情 |
Extended Information