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【结 构 式】 
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【分子编号】40213 【品名】2-(bromomethyl)quinoline 【CA登记号】5632-15-5 |
【 分 子 式 】C10H8BrN 【 分 子 量 】222.08426 【元素组成】C 54.08% H 3.63% Br 35.98% N 6.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Benzylic bromination of 2-methylquinoline (I) by means of N-bromosuccinimide afforded 2-(bromomethyl)quinoline (II). Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine, which was finally converted to the tetrahydrochloride salt.
| 【1】 Mikata, Y.; et al.; Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent. Chem Pharm Bull 2000, 48, 4, 477. |
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