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【结 构 式】 
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【药物名称】 【化学名称】N1,N2-Bis(2-quinolinylmethyl)ethane-1,2-diamine tetrahydrochloride 【CA登记号】 【 分 子 式 】C22H26Cl4N4 【 分 子 量 】488.29132 |
【开发单位】Nara Women's University (Originator) 【药理作用】DNA-Intercalating Drugs |
合成路线1
Benzylic bromination of 2-methylquinoline (I) by means of N-bromosuccinimide afforded 2-(bromomethyl)quinoline (II). Dimerization of (II) using ethylenediamine gave the corresponding bis(quinolylmethyl)ethylenediamine, which was finally converted to the tetrahydrochloride salt.
| 【1】 Mikata, Y.; et al.; Effect of the linking position of a side chain in bis (quinolymethyl)ethylenediamine as a DNA binding agent. Chem Pharm Bull 2000, 48, 4, 477. |
Extended Information