2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl benzoate -Drug Synthesis Database

【结构式】

【分子编号】39971

【品名】2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl benzoate

【CA登记号】

【分子式】C₁₅H₁₅N₅O₄

【分子量】329.3154

【元素组成】C 54.71% H 4.59% N 21.27% O 19.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

The condensation of guanine (IX) with refluxing hexamethyldisilazane followed by reaction with 1-benzoyloxy-2-chloromethoxyethane (IV) by means of triethylamine in refluxing benzene gives 9-(2-benzoyloxyethoxymethyl)guanine (X), which is finally hydrolyzed with ammonia in methanol at 80 C in a pressure vessel.

参考文献中间体

合成目标

【1】 Castaner, J.; Hillier, K.; Acycloguanosine. Drugs Fut 1978, 3, 11, 788.
【2】 Schaeffer, H.J. (Glaxo Wellcome plc); Purine derivs.. US 4294831 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IV)	39966	2-(chloromethoxy)ethyl benzoate	C₁₀H₁₁ClO₃	详情	详情
(IX)	39970	2-amino-9H-purin-6-ol	C₅H₅N₅O	详情	详情
(X)	39971	2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]ethyl benzoate	C₁₅H₁₅N₅O₄	详情	详情

Extended Information