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【结 构 式】 
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【分子编号】39970 【品名】2-amino-9H-purin-6-ol 【CA登记号】 |
【 分 子 式 】C5H5N5O 【 分 子 量 】151.1278 【元素组成】C 39.74% H 3.33% N 46.34% O 10.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)The condensation of guanine (IX) with refluxing hexamethyldisilazane followed by reaction with 1-benzoyloxy-2-chloromethoxyethane (IV) by means of triethylamine in refluxing benzene gives 9-(2-benzoyloxyethoxymethyl)guanine (X), which is finally hydrolyzed with ammonia in methanol at 80 C in a pressure vessel.
| 【1】 Castaner, J.; Hillier, K.; Acycloguanosine. Drugs Fut 1978, 3, 11, 788. |
| 【2】 Schaeffer, H.J. (Glaxo Wellcome plc); Purine derivs.. US 4294831 . |
Extended Information