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【结 构 式】 
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【分子编号】39960 【品名】triamcinolone cyclopentanonide 【CA登记号】55646-99-6 |
【 分 子 式 】C26H33FO6 【 分 子 量 】460.5428232 【元素组成】C 67.81% H 7.22% F 4.13% O 20.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III), which is then acetylated by reaction with acetic anhydride in pyridine.
| 【1】 Hillier, K.; Castaner, J.; Amcinodine. Drugs Fut 1978, 3, 5, 337. |
| 【2】 Sieger, G.M.; Krieger, C. (American Cyanamid Co.); Administration of 16alpha,17alpha-cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate. DE 2437847; FR 2240738; GB 1442925; US 4158055 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39959 | (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-17-glycoloyl-11,16,17-trihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one | 124-94-7 | C21H27FO6 | 详情 | 详情 |
| (II) | 15113 | cyclopentanone | 120-92-3 | C5H8O | 详情 | 详情 |
| (III) | 39960 | triamcinolone cyclopentanonide | 55646-99-6 | C26H33FO6 | 详情 | 详情 |
Extended Information