Amcinonide, CL-34699, -Drug Synthesis Database

【结构式】

【药物名称】Amcinonide, CL-34699

【化学名称】21-Acetoxy-9alpha-fluoro-11beta,16alpha,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal whith cyclopentanone
　　　　　　11beta,16alpha-Acetoxy-16,17[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione
　　　　　　16alpha,17alpha-Cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20dione 21-acetate

【CA登记号】51022-69-6

【分子式】C₂₈H₃₅FO₇

【分子量】502.58535

【开发单位】

【药理作用】　

合成路线1

9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III), which is then acetylated by reaction with acetic anhydride in pyridine.

参考文献中间体

【1】 Hillier, K.; Castaner, J.; Amcinodine. Drugs Fut 1978, 3, 5, 337.
【2】 Sieger, G.M.; Krieger, C. (American Cyanamid Co.); Administration of 16alpha,17alpha-cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate. DE 2437847; FR 2240738; GB 1442925; US 4158055 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39959	(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-17-glycoloyl-11,16,17-trihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one	124-94-7	C₂₁H₂₇FO₆	详情	详情
(II)	15113	cyclopentanone	120-92-3	C₅H₈O	详情	详情
(III)	39960	triamcinolone cyclopentanonide	55646-99-6	C₂₆H₃₃FO₆	详情	详情

Extended Information