• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】39635

【品名】1-(1H-indol-3-yl)-2-(4-piperidinyl)-1-ethanone

【CA登记号】

【 分 子 式 】C15H18N2O

【 分 子 量 】242.3208

【元素组成】C 74.35% H 7.49% N 11.56% O 6.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of N-carbobenzoxy-4-piperidylacetic acid (I) with refluxing SOCl2 yields the corresponding acyl chloride (II), which by condensation with indole (III) by means of methylmagnesium iodide (A) in ether gives rise to 3-indolyl-(4-piperidylmethyl)ketone (IV). Finally, this compound is reduced with LiAlH4 in THF.

1 Blancafort, P.; Owen, R.T.; Castañer, J.; Serradell, M.N.; Indalpine. Drugs Fut 1979, 4, 12, 873.
2 Champseix, A.; et al.; US 4064255 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 20225 iodo(methyl)magnesium 917-64-6 CH3IMg 详情 详情
(I) 39633 2-[1-(2-phenylacetyl)-4-piperidinyl]acetic acid C15H19NO3 详情 详情
(II) 39634 2-[1-(2-phenylacetyl)-4-piperidinyl]acetyl chloride C15H18ClNO2 详情 详情
(III) 15292 Indole; 1H-indole 120-72-9 C8H7N 详情 详情
(IV) 39635 1-(1H-indol-3-yl)-2-(4-piperidinyl)-1-ethanone C15H18N2O 详情 详情
Extended Information