N-(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)thiourea -Drug Synthesis Database

【结构式】

【分子编号】39599

【品名】N-(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)thiourea

【CA登记号】

【分子式】C₈H₁₄N₄S₂

【分子量】230.35812

【元素组成】C 41.71% H 6.13% N 24.32% S 27.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The reaction of N-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (I) with methyl iodide in methanol gives the corresponding thiouronium iodide (II), which is converted into the sulfate by treatment with IRA 401 ion-exchange resin. Finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (III) in refluxing water.

参考文献中间体

合成目标

【1】 Durant, G.J.; et al.; US 4013659 .
【2】 Serradell, M.N.; Hopkins, S.J.; Blancafort, P.; Castaner, J.; Impromidine. Drugs Fut 1979, 4, 9, 647.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	39599	N-(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)thiourea	C₈H₁₄N₄S₂	详情	详情
(II)	39600	[(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)amino](methylsulfanyl)methaniminium iodide	C₉H₁₇IN₄S₂	详情	详情
(III)	21507	3-(1H-imidazol-4-yl)-1-propanamine	C₆H₁₁N₃	详情	详情

Extended Information