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【结 构 式】 
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【药物名称】Impromidine hydrochloride, SK&F-92676-A3 【化学名称】N-[2-(1H-Imidazol-4-ylmethylsulfanyl)ethyl]-N'-[3-(5-methyl-1H-imidazol-4-yl)propyl]guanidine trihydrochloride 【CA登记号】65573-02-6, 55273-05-7 (free base) 【 分 子 式 】C14H26Cl3N7S 【 分 子 量 】430.83322 |
【开发单位】 【药理作用】 |
合成路线1
The reaction of N-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (I) with methyl iodide in methanol gives the corresponding thiouronium iodide (II), which is converted into the sulfate by treatment with IRA 401 ion-exchange resin. Finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (III) in refluxing water.
| 【1】 Durant, G.J.; et al.; US 4013659 . |
| 【2】 Serradell, M.N.; Hopkins, S.J.; Blancafort, P.; Castaner, J.; Impromidine. Drugs Fut 1979, 4, 9, 647. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39599 | N-(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)thiourea | C8H14N4S2 | 详情 | 详情 | |
| (II) | 39600 | [(2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl)amino](methylsulfanyl)methaniminium iodide | C9H17IN4S2 | 详情 | 详情 | |
| (III) | 21507 | 3-(1H-imidazol-4-yl)-1-propanamine | C6H11N3 | 详情 | 详情 |
Extended Information