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【结 构 式】

【分子编号】39496

【品名】2-(2-bromoethoxy)naphthalene; 2-bromoethyl 2-naphthyl ether

【CA登记号】

【 分 子 式 】C12H11BrO

【 分 子 量 】251.12274

【元素组成】C 57.4% H 4.42% Br 31.82% O 6.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Compound can be prepared in three different ways: 1) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol. 2) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with tetrolic acid ethyl ester (III) in refluxing n-butanol. 3) By condensation of 3-methylpyrazol-5-one (IV) with 2-(2-naphthyloxy)ethyl bromide (V) by means of NaH in DMF or by heating at 110 C.

1 Moeller, E.; et al.; US 4113957 .
2 Prous, J.R.; Hillier, K.; BAY-g-6575. Drugs Fut 1979, 4, 6, 396.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 39494 1-[2-(2-naphthyloxy)ethyl]hydrazine; 2-hydrazinoethyl 2-naphthyl ether C12H14N2O 详情 详情
(II) 11819 ethyl acetoacetate; ethyl 3-oxobutanoate;Acetoacetic ester;Ethyl beta-ketobutyrate;ethyl 3-oxobutyrate 141-97-9 C6H10O3 详情 详情
(III) 39495 ethyl 2-butynoate 4341-76-8 C6H8O2 详情 详情
(IV) 27345 5-methyl-2,4-dihydro-3H-pyrazol-3-one 108-26-9 C4H6N2O 详情 详情
(V) 39496 2-(2-bromoethoxy)naphthalene; 2-bromoethyl 2-naphthyl ether C12H11BrO 详情 详情
Extended Information