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【结 构 式】 
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【药物名称】Nafazatrom, Bay-g-6575 【化学名称】2,4-Dihydro-5-methyl-2-[2-(2-naphthalenyloxy)ethyl]-3H-pyrazol-3-one 【CA登记号】59040-30-1 【 分 子 式 】C16H16N2O2 【 分 子 量 】268.31812 |
【开发单位】Bayer (Originator) 【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, ONCOLYTIC DRUGS |
合成路线1
Compound can be prepared in three different ways: 1) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol. 2) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with tetrolic acid ethyl ester (III) in refluxing n-butanol. 3) By condensation of 3-methylpyrazol-5-one (IV) with 2-(2-naphthyloxy)ethyl bromide (V) by means of NaH in DMF or by heating at 110 C.
| 【1】 Moeller, E.; et al.; US 4113957 . |
| 【2】 Prous, J.R.; Hillier, K.; BAY-g-6575. Drugs Fut 1979, 4, 6, 396. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39494 | 1-[2-(2-naphthyloxy)ethyl]hydrazine; 2-hydrazinoethyl 2-naphthyl ether | C12H14N2O | 详情 | 详情 | |
| (II) | 11819 | ethyl acetoacetate; ethyl 3-oxobutanoate；Acetoacetic ester;Ethyl beta-ketobutyrate;ethyl 3-oxobutyrate | 141-97-9 | C6H10O3 | 详情 | 详情 |
| (III) | 39495 | ethyl 2-butynoate | 4341-76-8 | C6H8O2 | 详情 | 详情 |
| (IV) | 27345 | 5-methyl-2,4-dihydro-3H-pyrazol-3-one | 108-26-9 | C4H6N2O | 详情 | 详情 |
| (V) | 39496 | 2-(2-bromoethoxy)naphthalene; 2-bromoethyl 2-naphthyl ether | C12H11BrO | 详情 | 详情 |
Extended Information