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【结 构 式】 
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【分子编号】39467 【品名】3-(2-bromoacetyl)phenyl pivalate 【CA登记号】 |
【 分 子 式 】C13H15BrO3 【 分 子 量 】299.1643 【元素组成】C 52.19% H 5.05% Br 26.71% O 16.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)3'-Hydroxyacetophenone (I) is acylated with pivaloylchloride (II) to form 3'-pivaloyloxyacetophenone (III). The latter is brominated with bromine to 3'-pivaloyloxy-2-bromoacetophenone (IV), which in turn reacts with N-ethylbenzylamine (V) to form 3'-pivaloyloxy-2-(benzylethylamino)acetophenone (VI). This compound is debenzylated and reduced with H2 in the presence of Pd/C in isopropanol containing hydrochloric acid to yield etilefrine pivalate hydrochloride.
| 【1】 St Janiak, P.; Etilefrine Pivalate. Drugs Fut 1979, 4, 6, 413. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25331 | 3-hydroxyacetophenone; 1-(3-hydroxyphenyl)-1-ethanone | 121-71-1 | C8H8O2 | 详情 | 详情 |
| (II) | 13597 | 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride | 3282-30-2 | C5H9ClO | 详情 | 详情 |
| (III) | 39466 | 3-acetylphenyl pivalate | C13H16O3 | 详情 | 详情 | |
| (IV) | 39467 | 3-(2-bromoacetyl)phenyl pivalate | C13H15BrO3 | 详情 | 详情 | |
| (V) | 39468 | N-benzyl-N-ethylamine; N-benzyl-1-ethanamine | 14321-27-8 | C9H13N | 详情 | 详情 |
| (VI) | 39469 | 3-[2-[benzyl(ethyl)amino]acetyl]phenyl pivalate | C22H27NO3 | 详情 | 详情 |
Extended Information