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【结 构 式】

【分子编号】39467

【品名】3-(2-bromoacetyl)phenyl pivalate

【CA登记号】

【 分 子 式 】C13H15BrO3

【 分 子 量 】299.1643

【元素组成】C 52.19% H 5.05% Br 26.71% O 16.04%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

3'-Hydroxyacetophenone (I) is acylated with pivaloylchloride (II) to form 3'-pivaloyloxyacetophenone (III). The latter is brominated with bromine to 3'-pivaloyloxy-2-bromoacetophenone (IV), which in turn reacts with N-ethylbenzylamine (V) to form 3'-pivaloyloxy-2-(benzylethylamino)acetophenone (VI). This compound is debenzylated and reduced with H2 in the presence of Pd/C in isopropanol containing hydrochloric acid to yield etilefrine pivalate hydrochloride.

1 St Janiak, P.; Etilefrine Pivalate. Drugs Fut 1979, 4, 6, 413.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25331 3-hydroxyacetophenone; 1-(3-hydroxyphenyl)-1-ethanone 121-71-1 C8H8O2 详情 详情
(II) 13597 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride 3282-30-2 C5H9ClO 详情 详情
(III) 39466 3-acetylphenyl pivalate C13H16O3 详情 详情
(IV) 39467 3-(2-bromoacetyl)phenyl pivalate C13H15BrO3 详情 详情
(V) 39468 N-benzyl-N-ethylamine; N-benzyl-1-ethanamine 14321-27-8 C9H13N 详情 详情
(VI) 39469 3-[2-[benzyl(ethyl)amino]acetyl]phenyl pivalate C22H27NO3 详情 详情
Extended Information