【结 构 式】 |
【药物名称】Etilefrine pivalate hydrochloride, K-30052 【化学名称】DL-(±)-alpha-(Ethylaminoethyl)-3'-hydroxybenzyl alcohol 3'-(2,2-dimethylpropionate) hydrochloride 【CA登记号】42145-91-5, 709-55-7 (etilefoine), 85750-39-6 (free base) 【 分 子 式 】C15H24ClNO3 【 分 子 量 】301.81643 |
【开发单位】Fujisawa Deutschland (Originator) 【药理作用】Cardiovascular Diseases (Not Specified), CARDIOVASCULAR DRUGS |
合成路线1
3'-Hydroxyacetophenone (I) is acylated with pivaloylchloride (II) to form 3'-pivaloyloxyacetophenone (III). The latter is brominated with bromine to 3'-pivaloyloxy-2-bromoacetophenone (IV), which in turn reacts with N-ethylbenzylamine (V) to form 3'-pivaloyloxy-2-(benzylethylamino)acetophenone (VI). This compound is debenzylated and reduced with H2 in the presence of Pd/C in isopropanol containing hydrochloric acid to yield etilefrine pivalate hydrochloride.
【1】 St Janiak, P.; Etilefrine Pivalate. Drugs Fut 1979, 4, 6, 413. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25331 | 3-hydroxyacetophenone; 1-(3-hydroxyphenyl)-1-ethanone | 121-71-1 | C8H8O2 | 详情 | 详情 |
(II) | 13597 | 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride | 3282-30-2 | C5H9ClO | 详情 | 详情 |
(III) | 39466 | 3-acetylphenyl pivalate | C13H16O3 | 详情 | 详情 | |
(IV) | 39467 | 3-(2-bromoacetyl)phenyl pivalate | C13H15BrO3 | 详情 | 详情 | |
(V) | 39468 | N-benzyl-N-ethylamine; N-benzyl-1-ethanamine | 14321-27-8 | C9H13N | 详情 | 详情 |
(VI) | 39469 | 3-[2-[benzyl(ethyl)amino]acetyl]phenyl pivalate | C22H27NO3 | 详情 | 详情 |