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【结 构 式】

【分子编号】39227

【品名】 

【CA登记号】

【 分 子 式 】C12H21NO6

【 分 子 量 】275.30188

【元素组成】C 52.35% H 7.69% N 5.09% O 34.87%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

4-(tert-Butoxycarbonylamino)butyric acid (I) was activated as the corresponding mixed anhydride (II) by treatment with ethyl chloroformate and triethylamine. Subsequent coupling of (II) with 4-aminopyridine (III) afforded the title amide.

1 Leoni, A.; Villetti, G.; Morigi, R.; Pietra, C.; Andreani, A.; Locatelli, A.; Rambaldi, M.; 4-Aminopyridine derivatives with antiamnesic activity. Eur J Med Chem 2000, 35, 1, 77.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 39226 4-[(tert-butoxycarbonyl)amino]butyric acid;4-((tert-butoxycarbonyl)amino)butanoic acid 57294-38-9 C9H17NO4 详情 详情
(II) 39227   C12H21NO6 详情 详情
(III) 25661 4-pyridinamine; 4-aminopyridine 5044-74-5 C5H6N2 详情 详情
Extended Information